PART I. BASIC IMMUNOLOGY
CHAPTER 1. THE WORLD OF THE IMMUNE SYSTEM
-- Innate Immunity (Natural Killer Cells; Complement pathways)
-- Adaptive Immunity (Humoral immunity; Antibodies; Molecular features of immunoglobulins; Cell-mediated immunity)
CHAPTER 2. LYMPHOCYTES AND ANTIGENS
-- Antigen Recognition
-- Major Histocompatibility Complex (MHC)
-- MHC Polymorphism
-- T Cells and Antigen-presenting Cell Interaction
-- Antibody Production (Activation of B Cells; Interaction of B cells and T helper cells; Isotope switching)
CHAPTER 3. OTHER IMPORTANT COMPONENTS OF THE IMMUNE SYSTEM
-- Eosinophils
-- Basophils
-- Mast Cells
-- Cytokines (Classification of cytokines; Cytokines and disease)
PART II. CLINICAL IMMUNOLOGY
CHAPTER 4. HYPERSENSITIVITY
-- Type I Hypersenstitivity Reaction (IgE-mediated) (Allergic rhinitis)
-- Type II Hypersensitivity Reaction (Antibody-mediated) (Blood transfusion reaction)
-- Type III Hypersensitivity Reaction (Immune complex-mediated) (Serum sickness)
-- Type IV Hypersensitivity Reaction (Cell-mediated; Delayed type) (Mantoux reaction; Allergic contact dermatitis)
-- Eosinophils and Disease (Eosinophilia)
-- Mast Cells and Disease (Mastocytosis)
CHAPTER 5. AUTOIMMUNITY
-- Central Tolerance: T Cells
-- Peripheral Tolerance: T Cells
-- Central and Peripheral Tolerance: B Cells
-- Factors Predisposing to Autoimmunity
-- Mechanisms of Autoimmunity
-- Autoimmune Diseases (Diagnosis of autoimmune diseases; Hashimoto thyroiditis; Systemic lupus erythematosus; Rheumatoid arthritis; Sjogren syndrome; Scleroderma)
CHAPTER 6. COMMON DIAGNOSTIC TESTS
-- In Vivo Testing (Prick skin testing; Intradermal testing; Provocative in vivo tests; Patch tests)
-- In Vitro Testing (ELISA; Radioallergosorbent test; Western blotting; Precipitation; Agglutination; Direct and indirect immunofluorescence)
CHAPTER 7. IMMUNODEFICIENCY
-- Primary Immunodeficiency (Immunodeficiency affecting adaptive immunity; Immunodeficiency affecting humoral immunity; X-linked agammaglobulinemia; Common variable immunodeficiency; IgA deficiency; Hyper immunoglobulin E syndrome; T cell deficiency; DiGeorge syndrome; Combined B and T cell deficiency; Ataxia telangiectasia)
-- Secondary (Acquired) Immunodeficiency
-- Diagnosis of Immunodeficiency (Workup for primary immunodeficiencies of the innate immune system; Workup for primary immunodeficiences of the adaptive immune system)
-- Management of Immunodeficiency (Management of AIDS)
CHAPTER 8. VACCINATION
-- Immune Response to Vaccination
-- Types of Vaccines
-- Characteristics of an Ideal Vaccine
-- Recommended Vaccines for Children and Adults (including Pneumococcal vaccine; Human papillomavirus vaccine; Shingles vaccine)
-- Passive Immunotherapy (Primary immunodeficiency and the use of IVIG)
CHAPTER 9. TRANSPLANTATION
-- Types of Grafts
-- Graft Success
-- Graft Rejection
-- Graft-Versus-Host Disease
-- Current Practices in Organ Transplantation
CHAPTER 10. TUMOR IMMUNOLOGY
-- Classification of Malignant Tumors (Carcinogenesis) -- Risk and Predisposing Factors of Malignancies
-- Immune Response to Tumors (Immune surveillance and immunoediting; Elimination; Equilibrium, Escape)
-- Tumor Immunotherapy (Active immunotherapy; Passive immunotherapy)
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